Volume 13 Supplement 1
Homeostatic regulation in a single neuron model from the Pre-Bötzinger Complex
© Oginsky and Cymbalyuk; licensee BioMed Central Ltd. 2012
Published: 16 July 2012
Central Pattern Generators (CPGs) control rhythmic movements in diverse species ranging from decapods to mammals. For the same CPG, from preparation to preparation, the intrinsic membrane properties of CPG neurons are highly disparate and modulated, however the network output remains constant. This leads to questions regarding the coregulation of currents preserving essential dynamics of a neuron. When the fast-transient potassium current, IA, is increased in the pyloric dilator neuron of the stomatogastric ganglion, there is a compensatory increase in the hyperpolarization-activated current, IH. This prevents changes in the output of this well-studied CPG. Here, we test whether this coregulation would be effective if applied to the dynamics of another well-studied CPG found in mammals that controls breathing. We hypothesized that when the maximal conductance, ḡ A , of IA was increased there would be an increase in the period and interburst interval (IBI) and subsequently increasing the maximal conductance, ḡ H , of IH would provide a matching compensatory decrease. To investigate this, we modified a single neuron model of the pre-Bötzinger complex  by adding IA  and IH . We investigated this model by systematically exploring properties of the ionic currents.
This model shows that increasing IH opposes the effects of increasing IA in period, IBI, frequency and spike number. This may be a common mechanism for regulating rhythmic patterns in CPGs.
This research was supported by NSF grant PHY-0750456 to GC.
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