Volume 13 Supplement 1

Twenty First Annual Computational Neuroscience Meeting: CNS*2012

Open Access

Dynamics of large-scale neuronal networks of the human cortex functional connectivity

BMC Neuroscience201213(Suppl 1):P117

DOI: 10.1186/1471-2202-13-S1-P117

Published: 16 July 2012

Spatio-temporally organized low-frequency fluctuations (<0.1 Hz) of blood-oxygen-level-dependent (BOLD) fMRI signal have been intensively investigated as a measure of functional connectivity (FC) between region pairs in the whole brain [1]. Resting state FC is commonly assumed to be shaped by the underlying anatomical connectivity (AC). Furthermore, it has been suggested that the strength, persistence, and spatial properties of FC are constrained by the large-scale anatomical structure of the cortex [2]. However, strong resting state FC is often observed between pairs of remote cortical regions, even without apparent direct anatomical connections [3]. Mechanisms generating resting state FC are largely unknown, and it has been contended that indirect connections, interregional distance, and collective effects governed by network properties of the cortex play significant role. In addition, some theoretical studies on large-scale brain networks demonstrated the importance of time delays in networks dynamics for the generation of resting state FC fluctuations [4, 5]. To address these questions we investigate large-scale neural network model of human cortex FC. Our model is based on an empirically derived resting state FC network consisting of 64 region of interest (ROIs) (network nodes), which are chosen from all over the cortex. The ROIs are adapted from a study of functional segmentation of the brain cortex using high-model-order independent component analysis (ICA) [6]. There are 30 pairs of inter-hemispheric homologues, and 4 additional ROIs are chosen along the midline. The activity of each node is described by FitzHugh-Nagumo neurons. Network dynamics is modelled with different parameters for each node and different time delays to account for the finite signal propagation times between the nodes.

Authors’ Affiliations

(1)
Technische Universität Berlin
(2)
Bernstein Center for Computational Neuroscience Berlin
(3)
Northeastern University

References

  1. Bressler SL, Menon V: Large-scale brain networks in cognition: emerging methods and principles. Trends Cogn Sci. 2010, 14: 277-90. 10.1016/j.tics.2010.04.004.View ArticlePubMedGoogle Scholar
  2. Honey CJ, Sporns O, Cammoun L, Gigandet X, Thiran JP, Meuli R, Hagmann P: Predicting human resting-state functional connectivity from structural connectivity. Proc Natl Acad Sci U S A. 2009, 106: 2035-40. 10.1073/pnas.0811168106.PubMed CentralView ArticlePubMedGoogle Scholar
  3. Vincent JL, Patel GH, Fox MD, Snyder AZ, Baker JT, Van Essen DC, Zempel JM, Snyder LH, Corbetta M, Raichle ME: Intrinsic functional architecture in the anaesthetized monkey brain. Nature. 2007, 447: 83-6. 10.1038/nature05758.View ArticlePubMedGoogle Scholar
  4. Ghosh A, Rho Y, McIntosh AR, Kötter R, Jirsa VK: Cortical network dynamics with time delays reveals functional connectivity in the resting brain. Cogn Neurodyn. 2008, 2: 115-20. 10.1007/s11571-008-9044-2.PubMed CentralView ArticlePubMedGoogle Scholar
  5. Cabral J, Hugues E, Sporns O, Deco G: Role of local network oscillations in resting-state functional connectivity. Neuroimage. 2011, 57: 130-9. 10.1016/j.neuroimage.2011.04.010.View ArticlePubMedGoogle Scholar
  6. Kiviniemi V, Starck T, Remes J, Long X, Nikkinen J, Haapea M, Veijola J, Moilanen I, Isohanni M, Zang YF, Tervonen O: Functional segmentation of the brain cortex using high model order group PICA. Hum Brain Mapp. 2009, 30: 3865-86. 10.1002/hbm.20813.View ArticlePubMedGoogle Scholar

Copyright

© Vuksanović and Hövel; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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