Volume 13 Supplement 1

Twenty First Annual Computational Neuroscience Meeting: CNS*2012

Open Access

Synaptic activations of neuronal populations in the thalamocortical loop from LFP using kCSD and ICA

  • Szymon Łęski1Email author,
  • Helena Głąbska1,
  • Jan Potworowski1 and
  • Daniel K Wójcik1
BMC Neuroscience201213(Suppl 1):P11

DOI: 10.1186/1471-2202-13-S1-P11

Published: 16 July 2012

Local field potentials (LFP), the low-frequency part of the electric potential recorded extracellularly in the brain, is a well-established measure of neural activity at the population level. However, the origin and the nature of the LFP make it harder to interpret than other electrophysiological signals such as spikes. Two problems intertwine here: first, the extracellular field spreads over significant distances from the generating population; second, the recorded signal is typically a combination of contributions from several sources. The former problem is often addressed by reconstructing the underlying currents using Current Source Density (CSD) analysis. To solve the latter issue we have employed in the past the combination of CSD and Independent Component Analysis (ICA) [1].

Here we test the combination of CSD analysis [2] and ICA on simulated LFP data obtained from a computational model of a single thalamocortical column [3, 4]. We test how the components obtained by analyzing the full LFP are related to the ‘building blocks’ of population activity, that is the specific synaptic activations of individual populations of neurons. We show which populations can possibly be recorded with a limited number of electrodes and in the presence of noise, and discuss the limitations of the approach and ways to improve the reconstructions.

Declarations

Acknowledgements

We acknowledge financial support from the Polish Ministry of Science and Higher Education (grant N N303 542839) and from a project co-financed by the European Regional Development Fund under the Operational Programme Innovative Economy, POIG 02.03.00-00-018/08.

Authors’ Affiliations

(1)
Department of Neurophysiology, Nencki Institute of Experimental Biology

References

  1. Łęski S, Kublik E, Świejkowski DA, Wróbel A, Wójcik DK: Extracting functional components of neural dynamics with Independent Component Analysis and inverse Current Source Density. J Comput Neurosci. 2010, 29: 459-473. 10.1007/s10827-009-0203-1.View ArticlePubMedGoogle Scholar
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Copyright

© Łęski et al; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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