Volume 12 Supplement 1
Sensitivity analysis to explain the excitability in a pyramidal neuron with application to Alzheimer’s disease
© Nowacki et al; licensee BioMed Central Ltd. 2011
Published: 18 July 2011
Intrinsic excitability is one of the pillars of neuronal behaviour . Combined experimental and modelling studies of neuronal excitability often provide an important insight into the brain functions. In this work we analyse a unified model that we derived for CA1/3 pyramidal neurons in Hodgkin-Huxley formalism . We explore the variations of the model behaviour through parameter sensitivity analysis. Model validation against the experimental current clamp data shows that our model reproduces the behaviour of pyramidal cells very well. A characteristic feature of CA1/3 pyramidal cell response is a higher frequency of the first spike pairs. We define an excitability measure that quantifies parameter sensitivity in our model and takes into account this unique feature of the response.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.