Volume 12 Supplement 1
Modeling UBC intrinsic excitability
© Subramaniyam et al; licensee BioMed Central Ltd. 2011
Published: 18 July 2011
Here we present a biologically realistic multi-compartmental mathematical model of the UBC realized with the NEURON simulator. According to literature [1–4], ionic channels are distributed among compartments (soma, dendrite, and axon). The model can reproduce the excitable properties of UBCs in current-clamp and voltage-clamp modes. Attempts at modeling the response to mossy fiber inputs are ongoing. This model confirms the primary role of the aforementioned currents in UBC’s electroresponsiveness. The model will also be a valuable tool for investigating the UBC’s function in the cerebellar network.
This work was supported by the EU projects CEREBNET and REALNET to ED. SS is recipient of a grant from CEREBNET.
- Rossi DJ, Altford S, Mugnaini E, Slater NT: Properties of transmission at a giant glutamatergic synapse in cerebellum: the mossy fiber-unipolar brush cell synapse. J. Neurophysiol. 1995, 74 (1): 24-42.PubMedGoogle Scholar
- Diana MA, Otsu Y, Maton G, Collin T, Chat M, Dieudonné S: T-type and L-type Ca2+ conductances define and encode the bimodal firing pattern of vestibulocerebellar unipolar brush cells. J Neurosci. 2007, 27 (14): 3823-3838. 10.1523/JNEUROSCI.4719-06.2007.View ArticlePubMedGoogle Scholar
- Russo MJ, Yau HJ, Nunzu MG, Mugnaini E, Martina M: Dynamic metabotropic control of intrinsic fring in cerebellar unipolar brush cells. J Neurophysiol. 2008, 100 (6): 3351-3360. 10.1152/jn.90533.2008.PubMed CentralView ArticlePubMedGoogle Scholar
- Ruigrok TJH, Henshroek RA, Simpson JI: Spontaneous activity signatures of morphologically identified interneurons in the vestibulocerebellum. The Journal of Neuroscience. 2011, 31 (2): 712-724. 10.1523/JNEUROSCI.1959-10.2011.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.