Volume 12 Supplement 1
Effects of adaptation and synaptic plasticity on synchronization of coupled oscillating neurons
© Ladenbauer et al; licensee BioMed Central Ltd. 2011
Published: 18 July 2011
Synchronized oscillating activity in cortical circuits is a prevalent phenomenon and considered to be fundamental to cognitive function, selective attention and consciousness. In the present study we describe how spike-frequency adaptation (SFA) affects the synchronization properties of coupled neurons driven to repetitive firing, in dependence of axonal conduction delays and spike-timing-dependent plasticity (STDP).
We analyze networks of adaptive exponential integrate-and-fire (aEIF) neurons by applying phase reduction theory based on the assumption of weak coupling . We calculate infinitesimal phase response curves (PRCs) and combine these with conductance based AMPA- and GABA-like synapses, in order to obtain interaction functions which determine the dynamics of the reduced phase network. This allows for the identification of stable synchronous and out-of-phase locked states of coupled pairs. The aEIF model involves a subthreshold as well as a spike-triggered adaptation parameter which can be related to the M-current and the after hyperpolarization current, respectively, both producing SFA. The former causes a transition of the PRC from type I (only advancing) to type II (advancing and delaying) whereas the latter determines its skewness.
- Hoppensteadt FC, Izhikevich EM: Weakly Connected Neural Networks. . 1997, NewYork: Springer-VerlagGoogle Scholar
- Ermentrout B, Pascal M, Gutkin B: The effects of spike frequency adaptation and negative feedback on the synchronization of neural oscillators. Neural Computation. 2001, 13 (6): 1285-1310. 10.1162/08997660152002861.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.