Volume 12 Supplement 1

Twentieth Annual Computational Neuroscience Meeting: CNS*2011

Open Access

Identification of striatal cell assemblies suitable for reinforcement learning

BMC Neuroscience201112(Suppl 1):P228

DOI: 10.1186/1471-2202-12-S1-P228

Published: 18 July 2011

Both in vivo [1] and in vitro [2] experimental data suggest that medium spiny neurons in striatum participate in the formation of sequentially firing cell assemblies, at a timescale relevant for the presumed involvement of basal ganglia in reinforcement learning. Computational models argue that such cell assemblies are a feature of a minimal network architecture of the striatum [3]. This suggests that cell assemblies can be a potential candidate for representation of the 'system states' in the framework of reinforcement learning.

Spike patterns associated with cells assemblies can be identified by clustering the spectrum of zero-lag cross-correlation between all pairs of neurons in a network [3]. Other methods based on the dimensionality reduction of the similarity matrix of the spike trains have also been used [2, 4].

Here we investigate how the identification of cell assemblies is dependent on the methodology chosen, and to what extent the statistical properties of the cell assemblies make them suitable for representation of system states in the striatum during reinforcement learning.

Declarations

Acknowledgements

Partially funded by the German Federal Ministry of Education and Research (BMBF 01GQ0420 to BCCN Freiburg, BMBF GW0542 Cognition and BMBF 01GW0730 Impulse Control), EU Grant 269921 (BrainScaleS), Helmholtz Alliance on Systems Biology (Germany), Neurex, the Junior Professor Program of Baden-Württemberg and the Erasmus Mundus Joint Doctoral programme EuroSPIN.

Authors’ Affiliations

(1)
Functional Neural Circuits Group, Faculty of Biology, University of Freiburg
(2)
Bernstein Center Freiburg, University of Freiburg
(3)
Neurobiology and Biophysics, Faculty of Biology, University of Freiburg
(4)
Dept. Computational Biology, School of Computer Science and Communication, KTH

References

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Copyright

© Toledo-Suárez et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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