Volume 12 Supplement 1
A computational model of a strongly facilitating synapse
© Jędrzejewska-Szmek et al; licensee BioMed Central Ltd. 2011
Published: 18 July 2011
We propose a new model of strongly facilitating synapse. It is described in terms of resources R which can be in two states: available and inactivated (recovery constant –t γ ). It assumes that for the release of neurotransmitter to the synaptic cleft a fraction (u) of available resources must bu used (as in ). This fraction is elevated by every AP (by a factor ~ u*U) and decays in between APs (facilitation constant – t f ). u related to the calcium concentration. It is further assumed that the activation of the neurotransmitter release machinery requires binding of 5 calcium ions to synaptotagmin, binding synaptic vesicles to the presynaptic membrane. Hence the postsynaptic current is proportional to u5*R*δ(t-tAP).
Results of the models fit to the experimental data
Value and 68% confidence range in
10± 2 ms
0.18 ± 0.07
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