Volume 12 Supplement 1

Twentieth Annual Computational Neuroscience Meeting: CNS*2011

Open Access

The emergence of long timescales and stereotyped behaviors in C. elegans

  • Greg J Stephens1Email author,
  • Matthew Bueno de Mesquita2,
  • William S Ryu2 and
  • William Bialek1, 3
BMC Neuroscience201112(Suppl 1):P13

DOI: 10.1186/1471-2202-12-S1-P13

Published: 18 July 2011

Animal behaviors are often decomposable into discrete, stereotyped elements, well-separated in time. In one model, such behaviors are triggered by specific commands; in the extreme case, the discreteness of behavior is traced to the discreteness of action potentials in the individual command neurons. Here, we use the crawling behavior of the nematode C. elegans to demonstrate the opposite view, in which discreteness, stereotypy and long timescales emerge from the collective dynamics of the behavior itself. In previous work [1], we found that as C. elegans crawls, its body moves through a ``shape space'' in which four dimensions capture ~95% of the variance in body shape. Here we show that stochastic dynamics within this shape space predicts transitions between attractors corresponding to abrupt reversals in crawling direction. With no free parameters, our inferred stochastic dynamical system generates reversal time scales and stereotyped trajectories in close agreement with experimental observations. We use the stochastic dynamics to show that the noise amplitude decreases systematically with increasing time away from food, resulting in longer bouts of forward crawling and suggesting that worms can use noise to adaptive benefit.

Authors’ Affiliations

(1)
Lewis-Sigler Institute for Integrative Genomics and Physics Department, Princeton University
(2)
Physics Department and Banting and Best Department of Medical Research, University of Toronto
(3)
Princeton Center for Theoretical Science, Princeton University

References

  1. Stephens GJ, Johnson-Kerner B, Bialek W, Ryu WS: Dimensionality and dynamics in the behavior of C. elegans. PLoS Comp Bio. 2008, 4: e1000028-10.1371/journal.pcbi.1000028.View ArticleGoogle Scholar

Copyright

© Stephens et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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