Volume 11 Supplement 1
Supra-threshold stochastic resonance in a population of stochastic Hogkin-Huxley neuron models with random ion channel gating
© Mino; licensee BioMed Central Ltd. 2010
Published: 20 July 2010
Supra-threshold stochastic resonance (SSR) refers to a phenomenon what an optimally added noise can enhance information transmission when a supra-threshold signal is driven into an array of non-linear systems with threshold . The noise in neurons has been considered to come up from not only randomness of synaptic vesicle secretions (extrinsic fluctuations) but also stochasticity of ion channel gating (intrinsic fluctuations). However, it is still unclear whether and how those fluctuations help enhance information transmission in the case of supra-threshold input signals. The objective of this presentation was to see how randomness of ion channel gating could affect spike firing times and mutual information, and if SSR could be observed or not through computer simulations.
Methods and results
It follows that the mutual information was maximized at an optimal patch size in an array of stochastic HH neuron models, and therefore that SSR was observed in the presence of intrinsic fluctuations. This phenomenon may be aptly called ``intrinsic’’ SSR (ISSR). ISSR could play a key role in processing excessive input signals into sensory nervous systems.
- Stocks NG: Suprathreshold stochastic resonance in multilevel threshold systems. Phys. Rev. Lett. 2000, 84: 2310-2313. 10.1103/PhysRevLett.84.2310.View ArticlePubMedGoogle Scholar
- Mino H, et al.: Comparison of algorithms for the simulation of action potentials with stochastic sodium channels. Ann. Biomed. Eng. 2002, 30: 578-587. 10.1114/1.1475343.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd.