Volume 10 Supplement 1
Simulated networks with realistic neuronal morphologies show small-world connectivity
© de Ridder et al; licensee BioMed Central Ltd. 2009
Published: 13 July 2009
Activity dynamics underlying cognition depends crucially on the patterns and strengths of synaptic connections between neurons. Synaptic connections can form when axonal and dendritic branches of neurons come sufficiently close to each other . The geometry of neuronal arborization is therefore an important determinant of synaptic connectivity. How neuronal morphology shapes neuronal network connectivity is, however, still poorly understood.
Our preliminary findings indicate that realistic neuronal morphologies, simple synapse formation rules and independently developing neurons can already create networks with realistic connectivity patterns and small-world properties. Our study provides insight into the impact of neuronal geometry on network connectivity. In future work we will consider different cell types, different neuron densities and increased size of the network.
This work was supported by EU MC-RTN NEURoVERS-it (019247), and BIO-ICT Project SECO (216593).
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