Volume 10 Supplement 1
Activity-type dependent conductance relationships in a model neuron database
© Hudson and Prinz; licensee BioMed Central Ltd. 2009
Published: 13 July 2009
The stomatogastric ganglion (STG) of decapod crustaceans houses the neural circuit responsible for controlling the pyloric muscles. This neural network must produce robust rhythmic activity for successful digestion. This is a difficult task because each component cell of this system, identified by its predictable electrical activity, has a set of ion channel maximal conductances underlying its activity that varies from animal to animal. Recent experimental evidence suggests that coordinated expression and regulation of ion channels may play a role in constraining cellular electrical properties in the STG.
We conclude that regulating conductance ratios can support the maintenance of cellular activity type. Furthermore, our results show that negative correlations or correlations involving calcium conductances are plausible, and if implemented by a cell, would assist maintenance of a wide range of electrical activity types.
We would like to thank Dr. John Carew for advice on statistical analysis. This work is supported by 1 RO1 NS054911-01A1 from NINDS (A.A.P.) and a NSF IGERT award (A.E.H).
This article is published under license to BioMed Central Ltd.