Volume 10 Supplement 1

Eighteenth Annual Computational Neuroscience Meeting: CNS*2009

Open Access

Model of synaptic transmission in the calyx of Held

BMC Neuroscience200910(Suppl 1):P219

DOI: 10.1186/1471-2202-10-S1-P219

Published: 13 July 2009

The calyx of Held is a giant synaptic terminal in the MNTB of the auditory brainstem. Observations of postsynaptic responses to repeated stimulation reveal that this synapse exhibits complex behavior, which results from the interplay between processes such as vesicle pool depletion, activity-dependent recovery from depletion, synaptic facilitation and postsynaptic receptor desensitization. Intracellular calcium concentration ([Ca2+]) plays an important role in the neurotransmitter release and the regulation of short-term plasticity [1]. We build a detailed computational model of the synaptic transmission at the calyx, which captures all the above mentioned processes and includes the dynamics of calcium and its influence on the parameters of synaptic dynamics. The model is based on electrophysiological data obtained by patch clamp recordings from postsynaptic MNTB cells in rat brainstem slices. Calcium dynamics and the functional dependences of synaptic parameters on [Ca2+] are modeled based on previously published data [2]. Stimulating the synapse at different frequencies (from 0.2 to 200 Hz) and using pharmacological manipulations, we were able to separate contributions of different processes and determine the parameters of synaptic dynamics, which fit experimental data. We compare the fit with the previous phenomenological model [3], which does not include explicit dynamics of intracellular Ca2+.

Declarations

Acknowledgements

Supported by BMBF 01FQ0431 grant.

Authors’ Affiliations

(1)
Department of Membrane Biophysics, Max-Planck-Institute for Biophysical Chemistry
(2)
Network Dynamics Group, Max-Planck-Institute for Dynamics and Self-Organization
(3)
Bernstein Center for Computational Neuroscience

References

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Copyright

© Bibitchkov et al; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.

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