Volume 10 Supplement 1
Calcium sensor parameters and readout configurations for activity-dependent homeostatic regulation of pyloric network rhythms in the lobster stomatogastric ganglion
© Günay and Prinz; licensee BioMed Central Ltd. 2009
Published: 13 July 2009
In central pattern generating (CPG) neural networks, activity-dependent homeostatic regulation (ADHR) has been proposed to explain the experimentally observed robust activity that persists in spite of constant molecular turnover and environmental changes. In the pyloric CPG network of the lobster stomatogastric ganglion (STG), ADHR is dependent on and correlated with levels of intracellular calcium, which acts as a second messenger that affects ion channel and synaptic properties of the cell. Previous studies showed that calcium sensors can be used to maintain stable activity levels in individual model neurons  and pyloric rhythms in one model network . For regulation, these studies used deviations of the calcium current from a target value. However, they did not address the choice of sensor activation and inactivation variables, and the robustness of selected parameters and sensor configurations in the network. To address these issues, we developed a testbed that judges the quality of a sensor by using its readings to make a prediction about whether a network activity pattern is functional.
To make predictions, we used a classifier trained with sensor readings from a model pyloric network database . Based on their selected activity characteristics being similar to biological data, 2% of these networks were labeled as functional. In each testbed with different sensor placements and parameters, the percentage of functional networks correctly predicted by the classifier is indicated with a success rate.
This work is supported by 1 R01 NS054911-01A1 from NINDS and a Career Award at the Scientific Interface from the Burroughs Wellcome Fund awarded to AAP. R. Hooper and K.R Hammett contributed to preliminary results.
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This article is published under license to BioMed Central Ltd.