Activation of the pre-supplementary motor area but not inferior prefrontal cortex in association with short stop signal reaction time – an intra-subject analysis
© Chao et al; licensee BioMed Central Ltd. 2009
Received: 07 November 2008
Accepted: 14 July 2009
Published: 14 July 2009
Our previous work described the neural processes of motor response inhibition during a stop signal task (SST). Employing the race model, we computed the stop signal reaction time (SSRT) to index individuals' ability in inhibitory control. The pre-supplementary motor area (preSMA), which shows greater activity in individuals with short as compared to those with long SSRT, plays a role in mediating response inhibition. In contrast, the right inferior prefrontal cortex (rIFC) showed greater activity during stop success as compared to stop error. Here we further pursued this functional differentiation of preSMA and rIFC on the basis of an intra-subject approach.
Of 65 subjects who participated in four sessions of the SST, we identified 30 individuals who showed a difference in SSRT but were identical in other aspects of stop signal performance between the first ("early") and last two ("late") sessions. By comparing regional brain activation between the two sessions, we confirmed greater preSMA but not rIFC activity during short as compared to long SSRT session within individuals. Furthermore, putamen, anterior cerebellum and middle/posterior cingulate cortex also showed greater activity in association with short SSRT.
These results are consistent with a role of medial prefrontal cortex in controlled action and inferior frontal cortex in orienting attention. We discussed these findings with respect to the process of attentional monitoring and inhibitory motor control during stop signal inhibition.
Response inhibition allows flexible motor acts in changing environment. The stop signal task (SST) has been widely used to investigate the behavioral and neural processes of motor response inhibition [1, 2]. In the SST, there are "go" and "stop" trials. In the go trials, participants are required to respond to an imperative stimulus within a time window. Because go trials occur most of the time, they set up a prepotent response tendency. In the stop trials, an additional stop signal instructs participants to withhold their response. The rationale is that, when response inhibition is in place, participants are able to stop upon seeing the stop signal. Thus, many previous studies have compared stop success with stop error trials and identified bilateral or right inferior prefrontal cortex (IFC) as a cortical site of inhibitory motor control [3–5] (see also  for a review). However, an extensive literature has suggested that the IFC is part of the ventral attention system [7, 8]. Thus, by increasing activity in response to the stop signal (a behaviorally relevant external stimulus), the IFC may serve to orient attention and processing resources including those related to inhibitory control to the stop process and, as a result, facilitate stop signal inhibition.
In order to isolate the neural correlates independent of such attention-related activity, we proposed to follow the race model and computed the stop signal reaction time (SSRT) for individual subjects [1, 9]. By comparing participants with short and long SSRT who otherwise were indistinguishable in stop signal performance, we isolated the anterior pre-supplementary motor area (preSMA) as a potential cortical locus of response inhibition . However, this between-subject approach is amenable to demographic and behavioral confounds that go beyond the SST. For instance, impulsivity as a personality trait is known to influence cerebral activity during cognitive and affective processing [10, 11]. Furthermore, in a different cognitive control task, Forstmann and colleagues demonstrated that inter-subject variation in reaction time could provide useful information in model-based analyses of fMRI data, suggesting that an important dimension of inter-subject variability may elude "traditional" general linear modeling . Therefore, in order to avert potential confounds associated with such and other inter-subject factors, we attempted to confirm the role of pre-SMA in motor response inhibition on the basis of a within-subject approach. We took advantage of the multiple-session data that we have collected in healthy volunteers and compared regional brain activation between sessions in which participants showed a difference in SSRT. Importantly, participants did not differ in other performance measures between these short and long SSRT sessions. To anticipate, we replicated the finding of greater preSMA activity in association with short as compared to long SSRT.
Subjects and behavioral task
Sixty-five subjects (22 to 48 years of age, all right-handed, 32 men) were paid to participate in the study. All subjects signed a written consent after details of the study were explained, in accordance to institute guidelines and procedures approved by the Yale Human Investigation Committee. The study was carried out in compliance with the Helsinki Declaration.
The staircase procedure was also important for us to apply the race model in the computation of stop signal reaction time (SSRT) as an index of motor response inhibition [1, 2]. One way to understand the stop signal task is in terms of a race model with the go and stop processes racing toward a finishing line (Logan, 1994). The go process prepares and generates the movement while the stop process inhibits movement initiation: whichever process finishes first determines whether a response is initiated or not. Importantly, the go and stop processes race toward the activation threshold independently. Thus, the time required for the stop signal to be processed so a response is withheld (SSRT) can be computed on the basis of the go trial RT distribution and the odds of successful inhibits for different time delays between go and stop signals. This is done by estimating the critical SSD at which a response can be correctly stopped in approximately 50% of the stop trials. With the assumptions of this "horse-race" model, the SSRT could then be computed for each individual subject by subtracting the critical SSD from the median go trial RT. Generally speaking, the SSRT is the time required for a subject to cancel the movement after seeing the stop signal. A long SSRT indicates poor response inhibition.
In a within-subject analysis, we combined data of session 1 and 2 into an "early" session and data of session 3 and 4 into a "late" session. Because of the temporal contiguity of session 1 and 2, and session 3 and 4, we were able to examine whether participants' performance was adequate so we could compute the SSRT each for the early and late session. Thirty subjects showed a go trial success rate greater than 95% and a stop trial success rate within 50 ± 5%, suggesting that their performance is adequately tracked by the staircase procedure, during both early and late sessions. We estimated separately for the early and late session a critical SSD that represents the time delay between go and stop signals that a subject would require in order to succeed in 50% of the stop trials . Specifically, SSDs across trials were grouped into runs, with each run being defined as a monotonically increasing or decreasing series. We derived a mid-run estimate by taking the middle SSD (or average of two middle SSDs if there was an even number of SSDs) of every second run. The critical SSD was computed by taking the mean of all mid-run SSDs. It was reported that, except for experiments with a small number of trials (less than 30), the mid-run estimate was close to the maximum likelihood estimate of X50 (50% positive response; i.e., 50% SS in the SST, ). The SSRT was computed for individual subjects by subtracting the critical SSD from the median go trial RT each for the early and late session [1, 15].
Conventional T1-weighted spin echo sagittal anatomical images were acquired for slice localization using a 3T scanner (Siemens Trio). Anatomical images of the functional slice locations were next obtained with spin echo imaging in the axial plane parallel to the Anterior commissure – posterior commissure line with repetition time = 300 ms, echo time = 2.5 ms, bandwidth = 300 Hz/pixel, flip angle = 60°, field of view = 220 × 220 mm, matrix = 256 × 256, 32 slices with slice thickness = 4 mm and no gap. Functional, blood oxygenation level dependent (BOLD) signals were then acquired with a single-shot gradient echoplanar imaging (EPI) sequence. Thirty-two axial slices parallel to the AC-PC line covering the whole brain were acquired with TR = 2,000 ms, TE = 25 ms, bandwidth = 2004 Hz/pixel, flip angle = 85°, field of view = 220 × 220 mm, matrix = 64 × 64, 32 slices with slice thickness = 4 mm and no gap. Three hundred images were acquired in each session for a total of 4 sessions.
Data analysis and statistics
Data were analyzed with Statistical Parametric Mapping version 5 (Wellcome Department of Imaging Neuroscience, University College London, U.K.). Images from the first five TRs at the beginning of each trial were discarded to enable the signal to achieve steady-state equilibrium between RF pulsing and relaxation. Images of each individual subject were first corrected for slice timing, realigned (motion-corrected) and unwarped [17, 18]. A mean functional image volume was constructed for each subject for each session from the realigned image volumes. These mean images were normalized to an MNI (Montreal Neurological Institute) EPI template with affine registration followed by nonlinear transformation [19, 20]. The normalization parameters determined for the mean functional volume were then applied to the corresponding functional image volumes for each subject. Finally, images were smoothed with a Gaussian kernel of 10 mm at Full Width at Half Maximum. The data were high-pass filtered (128 s cutoff) to remove low-frequency signal drifts.
Four main types of trial outcome were first distinguished: go success (G), go error (F), stop success (SS), and stop error (SE) trial. A statistical analytical design was constructed each of the early and late session for individual subjects, using the general linear model (GLM) with the onsets of go signal in each of these trial types convolved with a canonical hemodynamic response function (HRF) and with the temporal derivative of the canonical HRF and entered as regressors in the model . Realignment parameters in all 6 dimensions were also entered in the model. Serial autocorrelation was corrected by a first-degree autoregressive or AR(1) model. The GLM estimated the component of variance that could be explained by each of the regressors.
In the first-level analysis, we constructed for individual subjects a contrast between SS and SE each for the early and late session. The con or contrast (difference in β) images of the first-level analysis were then used for the second-level group statistics (random effect analysis; ). Brain regions were identified using an atlas . Because of our hypothesis targeting the pre-supplementary motor area (preSMA) and right inferior prefrontal cortex (rIFC), we employed small volume correction to examine results specifically for these structures. The preSMA (MNI coordinate: x = -4, y = 36, z = 56) and rIFC (x = 44, y = 48, z = -12) masks were derived from our published work . In addition, we derived a second rIFC mask (a sphere of 10 mm in radius centered at x = 44, y = 12, z = 8) based on Aron and Poldrack, which reported a slightly different location of activation. All templates were in MNI space and voxel activations were presented in MNI coordinates. We used MarsBaR to derive for each individual subject the effect size of SS>SE for the ROIs .
Stop signal performance
Behavioral performance in the stop signal task, grouped by SSRT and "early" versus "late" session
180 ± 29
522 ± 122
98.3 ± 1.7
50.0 ± 3.2
1.18 ± 1.68
178 ± 27
504 ± 101
98.6 ± 1.6
51.5 ± 2.1
1.34 ± 1.20
1.81 ± 1.29
181 ± 31
539 ± 139
98.0 ± 1.7
48.7 ± 3.4
1.04 ± 1.79
2.75 ± 1.25
226 ± 29
529 ± 120
98.4 ± 1.3
50.3 ± 3.3
1.23 ± 1.62
2.32 ± 1.20
235 ± 26
514 ± 130
98.5 ± 1.3
51.4 ± 3.4
1.14 ± 1.52
2.51 ± 1.25
216 ± 30
546 ± 110
98.2 ± 1.4
49.1 ± 2.8
1.34 ± 1.71
2.11 ± 1.14
Because 16 subjects showed long SSRT during the early session (as compared to the late session) and 14 subjects showed the reverse, we needed to account for a potential "order" effect in the behavioral data. To this end, we performed a repeated measure analysis of variance (ANOVA) with SSRT (short vs. long) session as a within-subject variable and group (early vs. late session with short SSRT) as a between-subject variable. The results again showed no differences other than in SSRT between the short and long SSRT sessions (Table 1).
Region of interest analyses
Whole brain analyses
We conducted a SSRT (short vs. long) session by group (early vs. late session with short SSRT) mixed effect ANOVA, in order to account for the order effect. The results showed activity in the same brain regions but with diminished significance (p < 0.01, uncorrected, and 10 voxels in extent of activation), including right putamen: x = 28, y = -4, z = 0, voxel Z = 3.09; 3,648 mm3; anterior cerebellum: x = -4, y = -44, z = -12, voxel Z = 2.73, 1,472 mm3; and middle/posterior cingulate cortex: x = 8, y = -16, z = 40, voxel Z = 2.56, 704 mm3.
The stop signal task (SST) is widely used to investigate the behavioral and neural processes of motor inhibitory control [1, 2]. In studies employing fixed stop signal delays (SSD), an inhibitory function could be computed from stop success rate at these SSDs to index individuals' ability of inhibitory control. The inhibitory function or the stop signal reaction time (SSRT) computed from the inhibitory function can then be used in, for example, comparing patients and healthy controls (see  for a review) or tracking the development of inhibitory control through adolescence [30, 31]. In studies employing a staircase procedure (as in the current study), the SSRT can be computed directly for this purpose. Thus, in behavioral SST studies, there is much consistency as to what represents the outcome measure of inhibitory control.
The imaging literature presents a slightly complicated picture . For instance, many studies have compared stop and go trials directly in order to identify the neural processes of response inhibition [3, 32–34]. The rationale for this contrast perhaps is that the stop but not go process involves response inhibition. Compared to go trials, however, stop trials evoked more perceptual processing. Furthermore, response inhibition is not invariably evoked during stop trials, and subjects succeed or fail in inhibitions depending on whether this capacity is in place. Comparing stop and go trials without distinguishing stop success and error seems to be inconsistent with the underlying rationale of the SST. Other studies contrasted stop success and errors to isolate inhibitory control [4, 5]. However, successful performance in the SST depends on a number of other cognitive processes in addition to response inhibition. For instance, if participants watch for the stop signal, it is likely that this attention would expedite stop signal processing and facilitate the initiation of motor response inhibition.
We followed the race model by using the SSRT as an index of inhibitory control and identified the anterior pre-supplementary motor area (preSMA) as a brain region mediating response inhibition by comparing individuals with short and long SSRT . Thus, we replicated here greater activity in the preSMA in association with short SSRT on the basis of a within-subject analysis. In contrast, the inferior frontal cortices did not differentiate between short and long SSRT. These results stood when the order effect of the SSRT sessions was accounted for. We thus confirmed our hypothesis that this medial prefrontal area supports a role of inhibitory control, in keeping with its function in action selection and cognitive control shown in the literature [3, 35–49]. In contrast, the IFC is likely to be involved in attentional monitoring and allocation of processing resources, "kicking start" the stop process. Interestingly, consistent with bilateral IFC activation during stop success as compared to stop error [4, 5, 9], a recent work showed increased no-go errors in patients with left IFC lesions .
In whole brain analyses, we identified at a moderate threshold three additional structures related to stop signal inhibition, which were not observed in between-subject analyses: right putamen, middle/posterior cingulate cortex (PCC) and part of the vermis in the anterior cerebellum. The finding of right putamen activity in association with short SSRT directly contradicted our previous report which showed greater putamen activity in subjects with long compared to short SSRT . In fact, a recent study suggested that putamen is a target of prefrontal cortical action of motor inhibition . On the other hand, putamen lesion is known to cause apraxia, a loss of ability in goal-directed movement . Putamen is involved in the timing of sequential movements . In a unilateral motor task, the putamen in the ipsilateral hemisphere coactivated more strongly with the controlling motor cortex (contralateral to movement) than with the noncontrolling cortex, suggesting a complex role of putamen in motor control and its dependence on hemispherity . Studies also documented activity in the putamen and the cerebellar vermis in movement that requires bimanual coordination . Both putamen and cerebellum showed greater activation when participants were engaged in spatially incompatible (between hands) drawing than in spatially compatible drawing while the primary motor cortex showed the opposite pattern of response . Taken together, these studies suggested a role of the putamen in the control rather than simple execution of movement.
The PCC has been implicated in functional neuroimaging in a wide variety of cognitive and affective processes and in the pathogenesis of many neurological conditions . Although no studies have to our knowledge suggested a specific role of PCC in inhibitory control, a few earlier findings could be discussed with the current result. For instance, a recent magnetoencephalographic study illustrated the importance of enhanced perceptual processing of the stop stimulus in stop signal inhibition . In particular, the PCC appeared to be a critical site where this enhancement occurs and, via its interconnections with prefrontal structures, greater PCC activity facilitates stop signal inhibition . Other studies implicated a role of the PCC in motor response inhibition in different behavioral paradigms [60, 61]. For instance, in an attention cueing task, a spatial cue evoked greater activity in cortical structures including the retrosplenial PCC at a time when premature movement had to be withheld before the target appeared . Also of note is that the cingulate brain region we identified here did not appear to extend posteriorly to involve the retrosplenial cortex. Further studies were warranted to examine the specific roles of this cingulate region in motor inhibitory control.
We identified in association with short as compared to long SSRT the central lobule of the anterior cerebellum, part of the cerebellar vermis, a structure known to be important for motor control . In particular, cerebellum activates in response to timed movement which presumably involved a greater extent of inhibitory control, as compared to response to movement guided by external stimulus [63–66]. Similarly, non-predictive but not learned, predictable sequence of movement appeared to activate the vermis , potentially because the former required more moment-to-moment control. It has been suggested that cerebellar vermis is important for us to understand the neural processes underlying a number of psychiatric conditions, including attention deficit hyperactivity disorder [68–70], schizophrenia [71–73], bipolar disorder [74, 75], and cocaine  and alcohol [77–80] use disorders, in which deficits in inhibitory control are implicated. Thus, the finding of greater cerebellar activation in association with response inhibition may also be relevant to studies of these clinical conditions.
To summarize, we demonstrated greater activity in the pre-supplementary motor area (pre-SMA) but not the inferior frontal cortex (IFC) within individuals when their short SSRT session were compared to long SSRT session. This within-subjective analysis confirmed a distinct role of the preSMA in mediating stop signal inhibition, as described by the race model. The current findings, along with evidence from eletrophysiological studies [59, 81–83], suggest the importance of differentiating attentional monitoring and motor response inhibition in evaluating the neural processes underlying stop signal and go/no-go performance.
The current findings have some limitations. First, the findings on the putamen are inconsistent between the current work and Li et al., 2008 . We have reviewed the literature, which suggested a multifaceted and sometimes contradicting role of the putamen in motor control. However, the latter alone does not explain why opposite findings were obtained for the putamen in the current study. We speculated that inter-subject variability in aspects of the stop signal performance that have not yet been captured by our analyses may have accounted for this discrepancy. Second, although SSRT is generally taken to be a measure of motor inhibitory control [1, 2, 6, 84], a contrast between short and long SSRT may involve cognitive processes other than response inhibition. For instance, the preSMA has been implicated in motor awareness . Given that response inhibition during the stop signal task is likely more "controlled" (as opposed to "automatic" ), the role of preSMA in action awareness deserves careful consideration. Furthermore, preSMA along with other prefrontal and parietal structures showed greater activation during attentional shift when switching between target dimensions in stimulus categorization task, suggesting that an attentional component of inhibitory control cannot be ruled out in the current findings . Although it is difficult to directly compare fMRI of humans to unit recording studies in monkeys, a recent report also illustrated the complexity of determining a role of motor inhibitory control in the preSMA . Nakajima and colleagues trained macaque monkeys to perform a sequence of two movements and showed preSMA neuronal activity selective to the second-next movement. Such activity peaked before the initiation of the first movement, decayed thereafter, and remained low in magnitude when the animals initiated the second movement. The authors suggested that, while it could be a signal to inhibit a premature exertion of the second movement, such activity may serve to activate another group of neurons required for planning the second movement . Finally, a recent study appeared to suggest an opposite role of preSMA during decision making in a reaction time task . These authors observed that the preSMA showed greater activation when participants were cued for response speed as compared to accuracy. On the other hand, the location of the preSMA (x = 4, y = 5, z = 45) reported in this study did not seem to overlap the locale (x = -4, y = 36, z = 56) investigated in the current work. Taken together, the role of inhibitory motor control in the preSMA needs to be ascertained in further studies, with attention to possible functional subdivisions within the broad SMA/preSMA area.
- ANOVA :
analysis of variance
- BOLD :
blood oxygenation level dependent
- EPI :
- F :
- FP :
- G :
- GLM :
general linear model
- HRF :
hemodynamic response function
- IFC :
inferior (pre-)frontal cortex
- MNI :
Montreal Neurological Institute: PCC: posterior cingulate cortex
- PES :
- preSMA :
pre-supplementary motor area
- SE :
- SS :
- SSD :
stop signal delay
- SSRT :
stop signal reaction time
- SST :
stop signal task.
This study was supported by NIH grant R01DA023248 (Li), a research grant from the Alcoholic Beverage Medical Research Foundation (Li), and a Physician Scientist training grant (K12DA000167, Bruce Rounsaville).
- Logan GD: On the ability to inhibit thought and action: A user's guide to the stop signal paradigm. Inhibitory Processes in Attention. Edited by: Dagenbach D, Carr TH. 1994, Memory and Language, Academic Press, San Diego, 189-239.Google Scholar
- Logan GD, Cowan WB: On the ability to inhibit thought and action: A theory of an act of control. Psychol Rev. 1984, 91: 295-327. 10.1037/0033-295X.91.3.295.View ArticleGoogle Scholar
- Aron AR, Poldrack RA: Cortical and subcortical contributions to Stop signal response inhibition: role of the subthalamic nucleus. J Neurosci. 2006, 26: 2424-2433. 10.1523/JNEUROSCI.4682-05.2006.View ArticlePubMedGoogle Scholar
- Rubia K, Smith AB, Brammer MJ, Taylor E: Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection. Neuroimage. 2003, 20: 351-358. 10.1016/S1053-8119(03)00275-1.View ArticlePubMedGoogle Scholar
- Rubia K, Smith AB, Brammer MJ, Toone B, Taylor E: Abnormal brain activation during inhibition and error detection in medication-naïve adolescents with ADHD. Am J Psychiatry. 2005, 162: 1067-1075. 10.1176/appi.ajp.162.6.1067.View ArticlePubMedGoogle Scholar
- Verbruggen F, Logan GD: Response inhibition in the stop-signal paradigm. Trends Cogn Sci. 2008, 12: 418-424. 10.1016/j.tics.2008.07.005.PubMed CentralView ArticlePubMedGoogle Scholar
- Corbetta M, Patel G, Shulman GL: The reorienting system of the human brain: from environment to theory of mind. Neuron. 2008, 58: 306-324. 10.1016/j.neuron.2008.04.017.PubMed CentralView ArticlePubMedGoogle Scholar
- Corbetta M, Shulman GL: Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci. 2002, 3: 201-215. 10.1038/nrn755.View ArticlePubMedGoogle Scholar
- Li C-SR, Huang C, Constable T, Sinha R: Imaging response inhibition in a stop signal task – neural correlates independent of signal monitoring and post-response processing. J Neurosci. 2006, 26: 186-192. 10.1523/JNEUROSCI.3741-05.2006.View ArticlePubMedGoogle Scholar
- Congdon E, Canli T: The endophenotype of impulsivity: reaching consilience through behavioral, genetic, and neuroimaging approaches. Behav Cogn Neurosci Rev. 2005, 4: 262-281. 10.1177/1534582305285980.View ArticlePubMedGoogle Scholar
- Nomura M, Nomura Y: Psychological, neuroimaging, and biochemical studies on functional association between impulsive behavior and the 5-HT2A receptor gene polymorphism in humans. Ann N Y Acad Sci. 2006, 1086: 134-143. 10.1196/annals.1377.004.View ArticlePubMedGoogle Scholar
- Forstmann BU, Jahfari S, Scholte HS, Wolfensteller U, Wildenberg van den WP, Ridderinkhof KR: Function and structure of the right inferior frontal cortex predict individual differences in response inhibition: a model-based approach. J Neurosci. 2008, 28: 9790-9796. 10.1523/JNEUROSCI.1465-08.2008.View ArticlePubMedGoogle Scholar
- Li C-SR, Huang C, Yan P, Paliwal P, Constable RT, Sinha R: Neural correlates of post-error slowing in a stop signal task. J Cognit Neurosci. 2008, 20: 1021-1029. 10.1162/jocn.2008.20071.View ArticleGoogle Scholar
- De Jong R, Coles MG, Logan GD, Gratton G: In search of the point of no return: the control of response processes. J Exp Psychol Hum Percept Perform. 1990, 16: 164-182. 10.1037/0096-15184.108.40.206.View ArticlePubMedGoogle Scholar
- Levitt H: Transformed up-down methods in psychoacoustics. J Acoust Soc Am. 1970, 49: 467-477. 10.1121/1.1912375.View ArticleGoogle Scholar
- Wetherill GB, Chen H, Vasudeva RB: Sequential estimation of quantal response curves: A new method of estimation. Biometrika. 1966, 53: 439-454.View ArticleGoogle Scholar
- Andersson JL, Hutton C, Ashburner J, Turner R, Friston K: Modeling geometric deformations in EPI time series. Neuroimage. 2001, 13: 903-919. 10.1006/nimg.2001.0746.View ArticlePubMedGoogle Scholar
- Hutton C, Bork A, Josephs O, Deichmann R, Ashburner J, Turner R: Image distortion correction in fMRI: A quantitative evaluation. Neuroimage. 2002, 16: 217-240. 10.1006/nimg.2001.1054.View ArticlePubMedGoogle Scholar
- Ashburner J, Friston KJ: Nonlinear spatial normalization using basis functions. Hum Brain Mapp. 1999, 7: 254-266. 10.1002/(SICI)1097-0193(1999)7:4<254::AID-HBM4>3.0.CO;2-G.View ArticlePubMedGoogle Scholar
- Friston KJ, Ashburner J, Frith CD, Polone J-B, Heather JD, Frackowiak RSJ: Spatial registration and normalization of images. Hum Brain Mapp. 1995, 2: 165-189. 10.1002/hbm.460030303.View ArticleGoogle Scholar
- Friston KJ, Holmes AP, Worsley KJ, Poline J-B, Frith CD, Frackowiak RSJ: Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Mapp. 1995, 2: 189-210. 10.1002/hbm.460020402.View ArticleGoogle Scholar
- Penny W, Holmes AP: Random-effects analysis. Edited by: Frackowiak et al. 2004, Human Brain Function, Elsevier, San Diego, 843-850.Google Scholar
- Duvernoy HM: The Human Brain: Surface, Blood Supply, and Three-Dimensional Sectional Anatomy. 1999, Springer Verlag, New York, NY, SecondView ArticleGoogle Scholar
- Brett M, Anton J-L, Valabregue R, Poline J-P: Region of interest analysis using an SPM toolbox. Abstract presented at the 8th International Conference on Functional Mapping of the Human Brain, June 2–6. 2002, , Sendai, JapanGoogle Scholar
- Bertelson P, Tisseyre F: The time-course of preparation with regular and irregular foreperiods. Q J Exp Psychol. 1968, 20: 297-300. 10.1080/14640746808400165.View ArticlePubMedGoogle Scholar
- Li C-SR, Mathalon DH, Krystal JH: Fore-period effect and stop signal processing time. Exp Brain Res. 2005, 167: 305-309. 10.1007/s00221-005-0110-2.View ArticlePubMedGoogle Scholar
- Rabbit PMA: Errors and error correction in choice-response tasks. J Exp Psychol. 1996, 71: 264-272. 10.1037/h0022853.View ArticleGoogle Scholar
- Li C-SR, Milivojevic V, Kemp KA, Hong K, Sinha R: Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence. Drug Alcoh Depend. 2006, 85: 205-212. 10.1016/j.drugalcdep.2006.04.008.View ArticleGoogle Scholar
- Li C-SR, Sinha R: Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal-limbic dysfunction in psycho-stimulant addiction. Neurosci Biobehav Rev. 2008, 32: 581-597. 10.1016/j.neubiorev.2007.10.003.View ArticlePubMedGoogle Scholar
- Andrés P, Guerrini C, Phillips LH, Perfect TJ: Differential effects of aging on executive and automatic inhibition. Dev Neuropsychol. 2008, 33: 101-123. 10.1080/87565640701884212.View ArticlePubMedGoogle Scholar
- Leblanc N, Chen S, Swank PR, Ewing-Cobbs L, Barnes M, Dennis M, Max J, Levin H, Schachar R: Response inhibition after traumatic brain injury (TBI) in children: impairment and recovery. Dev Neuropsychol. 2005, 28: 829-848. 10.1207/s15326942dn2803_5.View ArticlePubMedGoogle Scholar
- Chevrier AD, Noseworthy MD, Schachar R: Dissociation of response inhibition and performance monitoring in the stop signal task using event-related fMRI. Hum Brain Mapp. 2007, 28: 1347-1358. 10.1002/hbm.20355.View ArticlePubMedGoogle Scholar
- Liddle PF, Kiehl KA, Smith AM: Event-related fMRI study of response inhibition. Hum Brain Mapp. 2001, 12: 100-109. 10.1002/1097-0193(200102)12:2<100::AID-HBM1007>3.0.CO;2-6.View ArticlePubMedGoogle Scholar
- Pliszka SR, Glahn DC, Semrud-Clikeman M, Franklin C, Perez R, Xiong J, Liotti M: Neuroimaging of inhibitory control areas in children with attention deficit hyperactivity disorder who were treatment naive or in long-term treatment. Am J Psychiatry. 2006, 163: 1052-1060. 10.1176/appi.ajp.163.6.1052.View ArticlePubMedGoogle Scholar
- Boecker H, Dagher A, Ceballos-Baumann AO, Passingham RE, Samuel M, Friston KJ, Poline J, Dettmers C, Conrad B, Brooks DJ: Role of the human rostral supplementary motor area and the basal ganglia in motor sequence control: investigations with H215O PET. J Neurophysiol. 1998, 79: 1070-1080.PubMedGoogle Scholar
- Boecker H, Jankowski J, Ditter P, Scheef L: A role of the basal ganglia and midbrain nuclei for initiation of motor sequences. Neuroimage. 2008, 39: 1356-1369. 10.1016/j.neuroimage.2007.09.069.View ArticlePubMedGoogle Scholar
- Brass M, Haggard P: To do or not to do: the neural signature of self-control. J Neurosci. 2007, 27: 9141-9145. 10.1523/JNEUROSCI.0924-07.2007.View ArticlePubMedGoogle Scholar
- de Jong BM, Paans AM: Medial versus lateral prefrontal dissociation in movement selection and inhibitory control. Brain Res. 2007, 1132: 139-147. 10.1016/j.brainres.2006.11.017.View ArticlePubMedGoogle Scholar
- Isoda M, Hikosaka O: Switching from automatic to controlled action by monkey medial frontal cortex. Nat Neurosci. 2007, 10: 240-248. 10.1038/nn1830.View ArticlePubMedGoogle Scholar
- Lau HC, Rogers RD, Haggard P, Passingham RE: Attention to intention. Science. 2004, 303: 1208-1210. 10.1126/science.1090973.View ArticlePubMedGoogle Scholar
- Leung HC, Cai W: Common and differential ventrolateral prefrontal activity during inhibition of hand and eye movements. J Neurosci. 2007, 27: 9893-9900. 10.1523/JNEUROSCI.2837-07.2007.View ArticlePubMedGoogle Scholar
- Mueller VA, Brass M, Waszak F, Prinz W: The role of the preSMA and the rostral cingulate zone in internally selected actions. Neuroimage. 2007, 37: 1354-1361. 10.1016/j.neuroimage.2007.06.018.View ArticlePubMedGoogle Scholar
- Nachev P, Rees G, Parton A, Kennard C, Husain M: Volition and conflict in human medial frontal cortex. Curr Biol. 2005, 15: 122-128. 10.1016/j.cub.2005.01.006.PubMed CentralView ArticlePubMedGoogle Scholar
- Rushworth MF, Hadland KA, Paus T, Sipila PK: Role of the human medial frontal cortex in task switching: a combined fMRI and TMS study. J Neurophysiol. 2002, 87: 2577-2592.PubMedGoogle Scholar
- Shima K, Mushiake H, Saito N, Tanji J: Role for cells in the presupplementary motor area in updating motor plans. Proc Natl Acad Sci (USA). 1996, 93: 8694-8698. 10.1073/pnas.93.16.8694.View ArticleGoogle Scholar
- Simmonds DJ, Pekar JJ, Mostofsky SH: Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent. Neuropsychologia. 2008, 46: 224-232. 10.1016/j.neuropsychologia.2007.07.015.PubMed CentralView ArticlePubMedGoogle Scholar
- Stuphorn V, Schall JD: Executive control of countermanding saccades by the supplementary eye field. Nat Neurosci. 2006, 9: 925-931. 10.1038/nn1714.View ArticlePubMedGoogle Scholar
- Sumner P, Nachev P, Morris P, Peters AM, Jackson SR, Kennard C, Husain M: Human medial frontal cortex mediates unconscious inhibition of voluntary action. Neuron. 2007, 54: 697-711. 10.1016/j.neuron.2007.05.016.PubMed CentralView ArticlePubMedGoogle Scholar
- Suskauer SJ, Simmonds DJ, Fotedar S, Blankner JG, Pekar JJ, Denckla MB, Mostofsky SH: Functional magnetic resonance imaging evidence for abnormalities in response selection in attention deficit hyperactivity disorder: differences in activation associated with response inhibition but not habitual motor response. J Cogn Neurosci. 2008, 20: 478-493. 10.1162/jocn.2008.20032.PubMed CentralView ArticlePubMedGoogle Scholar
- Swick D, Ashley V, Turken AU: Left inferior frontal gyrus is critical for response inhibition. BMC Neurosci. 2008, 21;9: 102-10.1186/1471-2202-9-102.View ArticleGoogle Scholar
- Li C-SR, Yan P, Sinha R, Lee TW: The subcortical processes of motor response inhibition during a stop signal task. NeuroImage. 2008, 41: 1352-1363. 10.1016/j.neuroimage.2008.01.068.PubMed CentralView ArticlePubMedGoogle Scholar
- Jaffard M, Longcamp M, Velay JL, Anton JL, Roth M, Nazarian B, Boulinguez P: Proactive inhibitory control of movement assessed by event-related fMRI. Neuroimage. 2008, 42: 1196-1206. 10.1016/j.neuroimage.2008.05.041.View ArticlePubMedGoogle Scholar
- Pramstaller PP, Marsden CD: The basal ganglia and apraxia. Brain. 1996, 119: 319-340. 10.1093/brain/119.1.319.View ArticlePubMedGoogle Scholar
- Garraux G, McKinney C, Wu T, Kansaku K, Nolte G, Hallett M: Shared brain areas but not functional connections controlling movement timing and order. J Neurosci. 2005, 25: 5290-5297. 10.1523/JNEUROSCI.0340-05.2005.View ArticlePubMedGoogle Scholar
- Marchand WR, Lee JN, Thatcher JW, Hsu EW, Rashkin E, Suchy Y, Chelune G, Starr J, Barbera SS: Putamen coactivation during motor task execution. Neuroreport. 2008, 19: 957-960. 10.1097/WNR.0b013e328302c873.View ArticlePubMedGoogle Scholar
- Kraft E, Chen AW, Flaherty AW, Blood AJ, Kwong KK, Jenkins BG: The role of the basal ganglia in bimanual coordination. Brain Res. 2007, 1151: 62-73. 10.1016/j.brainres.2007.01.142.View ArticlePubMedGoogle Scholar
- Wenderoth N, Toni I, Bedeleem S, Debaere F, Swinnen SP: Information processing in human parieto-frontal circuits during goal-directed bimanual movements. Neuroimage. 2006, 31: 264-278. 10.1016/j.neuroimage.2005.11.033.View ArticlePubMedGoogle Scholar
- Buckner RL, Andrews-Hanna JR, Schacter DL: The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 2008, 1124: 1-38. 10.1196/annals.1440.011.View ArticlePubMedGoogle Scholar
- Boehler CN, Münte TF, Krebs RM, Heinze HJ, Schoenfeld MA, Hopf JM: Sensory MEG Responses Predict Successful and Failed Inhibition in a Stop-Signal Task. Cereb Cortex. 2009, 19: 134-145. 10.1093/cercor/bhn063.View ArticlePubMedGoogle Scholar
- Hopfinger JB, Buonocore MH, Mangun GR: The neural mechanisms of top-down attentional control. Nat Neurosci. 2000, 3: 284-291. 10.1038/72999.View ArticlePubMedGoogle Scholar
- Mesulam MM, Nobre AC, Kim YH, Parrish TB, Gitelman DR: Heterogeneity of cingulate contributions to spatial attention. Neuroimage. 2001, 13: 1065-1072. 10.1006/nimg.2001.0768.View ArticlePubMedGoogle Scholar
- Ghez C, Thach WT: The Cerebellum. Principles of Neural Science. Edited by: Kandel ER, Schwartz JH, Jessell TM. 2000, McGraw-Hill, New York, NY, FourthGoogle Scholar
- Bengtsson SL, Ehrsson HH, Forssberg H, Ullén F: Dissociating brain regions controlling the temporal and ordinal structure of learned movement sequences. Eur J Neurosci. 2004, 19: 2591-2602. 10.1111/j.0953-816X.2004.03269.x.View ArticlePubMedGoogle Scholar
- Bengtsson SL, Ehrsson HH, Forssberg H, Ullén F: Effector-independent voluntary timing: behavioural and neuroimaging evidence. Eur J Neurosci. 2005, 22: 3255-3265. 10.1111/j.1460-9568.2005.04517.x.View ArticlePubMedGoogle Scholar
- Spencer RM, Verstynen T, Brett M, Ivry R: Cerebellar activation during discrete and not continuous timed movements: an fMRI study. Neuroimage. 2007, 36: 378-387. 10.1016/j.neuroimage.2007.03.009.PubMed CentralView ArticlePubMedGoogle Scholar
- Van Mier HI, Petersen SE: Role of the cerebellum in motor cognition. Ann N Y Acad Sci. 2002, 978: 334-353. 10.1111/j.1749-6632.2002.tb07578.x.View ArticlePubMedGoogle Scholar
- Nitschke MF, Stavrou G, Melchert UH, Erdmann C, Petersen D, Wessel K, Heide W: Modulation of cerebellar activation by predictive and non-predictive sequential finger movements. Cerebellum. 2003, 2: 233-240. 10.1080/14734220310005701.View ArticlePubMedGoogle Scholar
- Anderson CM, Lowen SB, Renshaw PF: Emotional task-dependent low-frequency fluctuations and methylphenidate: Wavelet scaling analysis of 1/f-type fluctuations in fMRI of the cerebellar vermis. J Neurosci Methods. 2006, 151: 52-61. 10.1016/j.jneumeth.2005.09.020.View ArticlePubMedGoogle Scholar
- Anderson CM, Polcari A, Lowen SB, Renshaw PF, Teicher MH: Effects of methylphenidate on functional magnetic resonance relaxometry of the cerebellar vermis in boys with ADHD. Am J Psychiatry. 2002, 159: 1322-1328. 10.1176/appi.ajp.159.8.1322.View ArticlePubMedGoogle Scholar
- Mackie S, Shaw P, Lenroot R, Pierson R, Greenstein DK, Nugent TF, Sharp WS, Giedd JN, Rapoport JL: Cerebellar development and clinical outcome in attention deficit hyperactivity disorder. Am J Psychiatry. 2007, 164: 647-655. 10.1176/appi.ajp.164.4.647.View ArticlePubMedGoogle Scholar
- Lee KH, Farrow TF, Parks RW, Newton LD, Mir NU, Egleston PN, Brown WH, Wilkinson ID, Woodruff PW: Increased cerebellar vermis white-matter volume in men with schizophrenia. J Psychiatr Res. 2007, 41: 645-651. 10.1016/j.jpsychires.2006.03.001.View ArticlePubMedGoogle Scholar
- Nopoulos PC, Ceilley JW, Gailis EA, Andreasen NC: An MRI study of cerebellar vermis morphology in patients with schizophrenia: evidence in support of the cognitive dysmetria concept. Biol Psychiatry. 1999, 46: 703-711. 10.1016/S0006-3223(99)00093-1.View ArticlePubMedGoogle Scholar
- Okugawa G, Sedvall GC, Agartz I: Smaller cerebellar vermis but not hemisphere volumes in patients with chronic schizophrenia. Am J Psychiatry. 2003, 160: 1614-1617. 10.1176/appi.ajp.160.9.1614.View ArticlePubMedGoogle Scholar
- Cecil KM, DelBello MP, Sellars MC, Strakowski SM: Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders. J Child Adolesc Psychopharmacol. 2003, 13: 545-555. 10.1089/104454603322724931.View ArticlePubMedGoogle Scholar
- Chang K, Adleman NE, Dienes K, Simeonova DI, Menon V, Reiss A: Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: a functional magnetic resonance imaging investigation. Arch Gen Psychiatry. 2004, 61: 781-792. 10.1001/archpsyc.61.8.781.View ArticlePubMedGoogle Scholar
- Anderson CM, Maas LC, Frederick B, Bendor JT, Spencer TJ, Livni E, Lukas SE, Fischman AJ, Madras BK, Renshaw PF, Kaufman MJ: Cerebellar vermis involvement in cocaine-related behaviors. Neuropsychopharmacology. 2006, 31: 1318-1326. 10.1038/sj.npp.1300922.View ArticlePubMedGoogle Scholar
- De Bellis MD, Narasimhan A, Thatcher DL, Keshavan MS, Soloff P, Clark DB: Prefrontal cortex, thalamus, and cerebellar volumes in adolescents and young adults with adolescent-onset alcohol use disorders and comorbid mental disorders. Alcohol Clin Exp Res. 2005, 29: 1590-1600. 10.1097/01.alc.0000179368.87886.76.View ArticlePubMedGoogle Scholar
- O'Hare ED, Kan E, Yoshii J, Mattson SN, Riley EP, Thompson PM, Toga AW, Sowell ER: Mapping cerebellar vermal morphology and cognitive correlates in prenatal alcohol exposure. Neuroreport. 2005, 16: 1285-1290. 10.1097/01.wnr.0000176515.11723.a2.View ArticlePubMedGoogle Scholar
- Sullivan EV, Rose J, Pfefferbaum A: Effect of vision, touch and stance on cerebellar vermian-related sway and tremor: a quantitative physiological and MRI study. Cereb Cortex. 2006, 16: 1077-1086. 10.1093/cercor/bhj048.View ArticlePubMedGoogle Scholar
- Sullivan EV: Compromised pontocerebellar and cerebellothalamocortical systems: speculations on their contributions to cognitive and motor impairment in nonamnesic alcoholism. Alcohol Clin Exp Res. 2003, 27: 1409-1419. 10.1097/01.ALC.0000085586.91726.46.View ArticlePubMedGoogle Scholar
- Knyazev GG, Levin EA, Savostyanov AN: A failure to stop and attention fluctuations: an evoked oscillations study of the stop-signal paradigm. Clin Neurophysiol. 2008, 119: 556-567. 10.1016/j.clinph.2007.11.041.View ArticlePubMedGoogle Scholar
- Kopp B, Tabeling S, Moschner C, Wessel K: Temporal dynamics of selective attention and conflict resolution during cross-dimensional Go-NoGo decisions. BMC Neurosci. 2007, 8: 68-10.1186/1471-2202-8-68.PubMed CentralView ArticlePubMedGoogle Scholar
- Ramautar JR, Kok A, Ridderinkhof KR: Effects of stop-signal probability in the stop-signal paradigm: the N2/P3 complex further validated. Brain Cogn. 2004, 56: 234-252.View ArticlePubMedGoogle Scholar
- Band GP, Molen van der MW, Logan GD: Horse-race model simulations of the stop-signal procedure. Acta Psychol (Amst). 2003, 112: 105-42. 10.1016/S0001-6918(02)00079-3.View ArticleGoogle Scholar
- Verbruggen F, Logan GD: Automatic and controlled response inhibition: associative learning in the go/no-go and stop-signal paradigms. J Exp Psychol Gen. 2008, 137: 649-72. 10.1037/a0013170.PubMed CentralView ArticlePubMedGoogle Scholar
- Morton JB, Bosma R, Ansari D: Age-related changes in brain activation associated with dimensional shifts of attention: an fMRI study. Neuroimage. 2009, 46: 249-56. 10.1016/j.neuroimage.2009.01.037.View ArticlePubMedGoogle Scholar
- Nakajima T, Hosaka R, Mushiake H, Tanji J: Covert representation of second-next movement in the pre-supplementary motor area of monkeys. J Neurophysiol. 2009, 101: 1883-9. 10.1152/jn.90636.2008.View ArticlePubMedGoogle Scholar
- Forstmann BU, Dutilh G, Brown S, Neumann J, von Cramon DY, Ridderinkhof KR, Wagenmakers EJ: Striatum and pre-SMA facilitate decision-making under time pressure. Proc Natl Acad Sci USA. 2008, 105: 17538-42. 10.1073/pnas.0805903105.PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.